1.病原菌核酸疫苗和佐剂研发
2.自噬与细菌性感染研究
3.病原菌与宿主互作机制研究
4.新型抗菌药物联用研究

1. Lv Z, Zhang X, Zhao K, Du L, Wang X, Chu Y, Huang T*. Co-immunization with DNA vaccines encoding yidR and IL-17 augments host immune response against Klebsiella pneumoniae infection in mouse model. Virulence. 2024; 15(1):2345019.(中科院1区TOP)
2. Song X, Huang T, Yan X, Zuo M, Pan Y, He H, Li Y, Zou Y, Du C, Zheng F, Yang T*. The pederin-producing bacteria density dynamics in Paederus fuscipes at different developmental stages. Med Vet Entomol. 2024; 38(1):59-72.(并列一作)
3. Zhao K, Yang X, Zeng Q, Zhang Y, Li H, Yan C, Li JS, Liu H, Du L, Wu Y, Huang G, Huang T, et al. Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung. Nat Commun. 2023;14(1):5976. (中科院1区TOP)
4. Du L, Geng C, Zeng Q, Huang T, Tang J, Chu Y, Zhao K*. Dockey: a modern integrated tool for large-scale molecular docking and virtual screening. Brief Bioinform. 2023; 24(2):bbad047. (中科院2区TOP)
5. Huang T, Lv Z, Cui K, Wang XR, Zhang XY, Yue BS, Chu YW*, Zhao KL*. Involvement of the E3 ubiquitin ligase Cblb in host defense and evaluation of transcriptome during Trueperella pyogenes infection. Microbes Infect. 2023; 105104.
6. Huang T*, Lv Z, Lin J, Zhao K, Zhai L, Wang X*, Chu Y*. A Potent Antibiotic Combination of Linezolid and Polymycin B Nonapeptide Against Klebsiella pneumoniae Infection In Vitro and In Vivo. Front Pharmacol. 2022;13:887941. (中科院2区TOP)
7. Huang T*, Zhao K, Song X, Song T, Wang X, Zhang X, Yue B, Chu Y*. Heterologous Prime-Boost Immunization with DNA Vaccine and Modified Recombinant Proteins Enhances Immune Response against Trueperella pyogenes in Mice. Vaccines (Basel). 2022;10(6):839.
8. Huang T, Zeng M, Fu H, Zhao K, Song T, Guo Y, Zhou J, Zhai L, Liu C, Prithiviraj B, Wang X*, Chu Y*. A novel antibiotic combination of linezolid and polymyxin B octapeptide PBOP against clinical Pseudomonas aeruginosa strains. Ann Clin Microbiol Antimicrob. 2022;21(1):38.
9. Huang T, Zhang J, Diotti RA, Pu Q. Editorial: Breakthroughs in immunotherapies and precision treatment against infectious diseases. Front Cell Infect Microbiol. 2022;12:953312.
10. Huang T, Liu L, Lv Z, Zhao K, Yi Q, Zhang J. Recent Advances in DNA Vaccines against Lung Cancer: A Mini Review. Vaccines (Basel). 2022;10(10):1586. (invited review)
11. Li J, Chen X*, Lin J, Yuan Y, Huang T, Du L, Prithiviraj B, Zhang A, Wang X, Chu Y, Zhao K*. Antibiotic intervention redisposes bacterial interspecific interacting dynamics in competitive environments. Environ Microbiol. 2021;23(12):7432-7444. (中科院2区TOP)
12. Huang T, Pu Q, Zhou C, Lin P, Gao P, Zhang X, Chu Y, Yue B, Wu M. MicroRNA-302/367 Cluster Impacts Host Antimicrobial Defense via Regulation of Mitophagic Response Against Pseudomonas aeruginosa Infection. Front Immunol. 2020;11:569173. (中科院2区TOP)
13. Zhao K, Huang T, Lin J, Yan C, Du L, Song T, Li J, Guo Y, Chu Y, Deng J, Wang X, Liu C, Zhou Y. Genetic and Functional Diversity of Pseudomonas aeruginosa in Patients With Chronic Obstructive Pulmonary Disease. Front Microbiol. 2020: 29;11:598478. (中科院2区TOP)
14. Zhao K, Li W, Li J, Ma T, Wang K, Yuan Y, Li JS, Xie R, Huang T, et al. TesG is a type I secretion effector of Pseudomonas aeruginosa that suppresses the host immune response during chronic infection. Nat Microbiol. 2019;4(3):459-469. (中科院1区TOP)
15. Huang T, Cui K, Song X, Jing J, Lin J, Wang X, Zhang X, Chu Y*, Yue B*. MTOR involved in bacterial elimination against Trueperella pyogenes infection based on mice model by transcriptome and biochemical analysis. Vet Microbiol. 2019;235:199-208.  (中科院2区TOP)
16. Zhao K, Li J, Huang T, Yuan Y, Lin J, Yue B, Wang X, Chu Y. Coexistence of Microbial Species in Structured Communities by Forming a Hawk-Dove Game Like Interactive Relationship. Front Microbiol. 2019; 10:807. (中科院2区TOP)
17. Zhao K, Liu L, Chen X, Huang T, Du L, Lin J, Yuan Y, Zhou Y, Yue B, Wei K, Chu Y*. Behavioral heterogeneity in quorum sensing can stabilize social cooperation in microbial populations. BMC Biol. 2019; 17(1):20. (中科院1区TOP)
18. Hoggarth A, Weaver A, Pu Q, Huang T, Schettler J, Chen F, Yuan X, Wu M*. Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa. Drug Des Devel Ther. 2019;13:909-924.
19. Pu Q, Zhao Y, Sun Y, Huang T, Lin P, Zhou C, Qin S, Singh BB, Wu M*. TRPC1 intensifies house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and STAT3/NF-κB signaling. FASEB J. 2019;33(1):1074-1085.  (中科院2区TOP)
20. Huang T, Song X, Jing J, Zhao K, Shen Y, Zhang X, Yue B*. Chitosan-DNA nanoparticles enhanced the immunogenicity of multivalent DNA vaccination on mice against Trueperella pyogenes infection. J Nanobiotechnology. 2018;16(1):8. (中科院1区TOP)
21. Huang T, Song X, Zhao K, Jing J, Shen Y, Zhang X, Yue B*. Quorum-sensing molecules N-acyl homoserine lactones inhibit Trueperella pyogenes infection in mouse model. Vet Microbiol. 2018;213:89-94.  (中科院2区TOP)
22. Zhao K, Li W, Huang T, Song X, Zhang X, Yue B*. Comparative transcriptome analysis of Trueperella pyogenes reveals a novel antimicrobial strategy. Arch Microbiol. 2017;199(5):649-655.
23. Huang T, Zhao K, Zhang Z, Tang C, Zhang X, Yue B*. DNA vaccination based on pyolysin co-immunized with IL-1β enhances host antibacterial immunity against Trueperella pyogenes infection. Vaccine. 2016;34(30):3469-77.
24. Huang T, Yan C, Tan Z, Tu F, Yue B, Zhang X*. Complete mitochondrial genome sequence of Nectogale elegans. Mitochondrial DNA. 2014;25(4):253-4.

（一）科研项目
1.国家自然科学基金青年项目，2020/01-2022/12，主持。
2.成都大学引进人才启动项目，2018/08-2021/08，主持。
3.成都大学川抗所国合基地开发课题，2021/12-2023/12，主持。
4.眉山市科学技术计划项目，2022/09-2023/07，主持。
5.四川省抗感染药物创制工程研究中心开放课题，2023/05- 2024/05，主持。
6.成都大学高层次人才培育项目，2024/01-2028/12，主持。
7.国家自然科学基金面上项目，2020/01-2023/12，主研。
8.四川省杰出青年科技人才项目，2021/04-2024/04，参与；
（二）教学成果
1.成都大学第二批校级一流课程项目，2021年，主持。