研究方向 |
药理学:抗衰老(黑色素代谢)与环境医学防护(热射病)方向;<br>
研究平台:现有斑马鱼快速药物筛选与评价系统,细胞与分子药理相关机制研究平台,在中药民族药物质基础研究领域建立了环境应激相似性的快速筛选与靶点预测模型。<br> 标志性成果:以氧还调控为科学原理,研发出“基于氧还调控理论的MIP复合荧光组学的毒物早期预警关键技术”,在医药工业领域建立了细胞微观超灵敏快速检测装置,该技术与荧光探针标记示踪技术相结合,构建了物理、化学、生物信号转化成电信号的新型传感分析筛选平台,在临床诊断、食品安全、药品生产过程中等多家医院与企业得到了推广应用。代表成果获省级科技进步一等奖2项(2014, 2017),省高校自然科学二等奖1项(2019)。 |
发表论文 |
第一作者及通讯作者SCI代表作:<br> 1.Chen, P.; Ji, X.-Y.; Feng, J.-T.; Wang, X.-Q.; Zhang, B*. The Synergistic Mechanism of Chelidonium majus Alkaloids on Melanoma Treatment via a Multi-Strategy Insight. Molecules 2024,29:5412<br> 2.Ma SZ, Dong S, Zhou ZY, Ji XY, Zhang YY, Wang XQ, Zhang B*. The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway. J Ethnopharmacol. 2024,334:118565<br> 3.Ji XY, Feng JT, Zhou ZY, Zhang YY, Ma SZ, Wang XQ, Zhang B*. Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway. Phytomedicine. 2024,132:155853<br> 4.Dong S, Liu Z, Chen H, Ma S, Wang F, Shen H, Li H, Zhang B*. A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD. Phytomedicine. 2024,132:155664<br> 5. Zhang J, You S, Yu L, Zhang Y, Li Z, Zhao N, Zhang B*, Kang L*, Sun S*. The hysteresis damage of cold exposure on tissue and transcript levels in mice. J Therm Biol. 2024,120:103823<br> 6.Dong S, Han J, Sun XY, Zhang B*, Wang W*, A novel 2D g-C3N4 material applied for Paraquat adsorbing and detoxifying in vitro and in vivo. Ecotox Environ Safe, 2023, 266,115594<br> 7.Luo Q, Ji XY, Zhang L, Huang X, Wang XQ, Zhang B*.Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways. Biomed Pharmacother, 2023,166:115346<br> 8.Wei H, Li ZX, Ji XY, Wang XQ, Zhang B*.Why do red- and yellow-colored edible herbs create warmth? A system pharmacological view of curcumin-mediated protection of mice from cold stress. J Funct Food, 2023,108:105726<br> 9.Wang QQ, Sun QR, Ji XY, Tang Y, Zhang K, Wang XQ, Li HR, Huang XZ*, Zhang B*.The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data. J Ethnopharmcol, 2022,303,115990<br> 10.Zhang Y, Deng X, Zhang J, Zhang L, Akram Z, Zhang B*, Sun S*. A Potential Driver of Disseminated Intravascular Coagulation in Heat Stroke Mice: Neutrophil Extracellular Traps. Int J Environ Res Public Health. 2022, 19:12448.<br> 11.Ding Q, Luo L, Yu L, Huang SL, Wang XQ, Zhang B*,The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis, Free Radical Bio Med, 2021, 176:392-405<br> 12.Wang J, Luo L, Ding Q, Wu Z, Peng Y, Li J, Wang X, Li W, Liu G, Zhang B* and Tang Y* (2021) Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods. Front Pharmacol 2021,12:754175<br> 13.Deng YX, Zhong J, Liu ZJ, Wang XQ*, Zhang B*, Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment. J Ethnopharmcol, 2021, 265, 113385<br> 14.Zhang J, Yang ZH, Zhang SS, Xie ZZ, Han SC, Wang LX, Zhang B*, Sun SG*. Investigation of endogenous malondialdehyde through fluorescent probe MDA-6 during oxidative stress. Analytica Chimica Acta, 2020,1116, 9-15<br> 15.Chai BY, Gong FK, Chen ZH, Li ZX, Zhang B*. System prediction and validation of TCM for chronic myeloid leukemia treatment from the perspective of low-toxicity chemotherapy: a stilbene a-viniferin has a pro-apoptotic effect on K562 cells via the mitochondrial pathway. Evid-Based Comple Alt, 2020, 1986962<br> 16.Liu ZJ, Zhong J,Zhang M, Chen ZH,Wang JY, Chen HY, Wang XQ, Zhang B*.The alexipharmic mechanisms of five licorice ingredients involved in CYP450 and Nrf2 pathways in paraquat-induced mice acute lung injury. Oxid Med Cell Longev, 2019, 7283104<br> 17.Wang J Y, Chen H, Wang YY,Wang XQ, Chen H Y, Zhang M ,Tang Y*, Zhang B*. Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst biol, 2017,11:103<br> 18.Zhang B, Liu J, Ma XR, Zuo P, Ye BC, Li YC, Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors, Biosens Bioelectron, 2016, 80: 491-496<br> 19.Zhang B, Fu YX, Huang C, Zheng CL, Wu ZY et al., New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep-UK.2016, 6, 21872<br> 20.Zhang B, Wang X Q*, Chen H Y, Liu B H. Involvement of the Nrf2 Pathway in the Regulation of Pterostilbene-Induced Apoptosis in HeLa Cells via ER Stress. J Pharmacol Sci, 2014,126:216-229 21.Zhang B, Xie C, Zhong J, Chen HY, Zhang HY, Wang XQ*. A549 cell proliferation inhibited by RNAi mediated silencing of the Nrf2 gene. Bio-med Mater Eng, 2014, 24: 3905-3916<br> 22.Zhang B, Chen N, Chen H, Wang Z, Zheng Q. The critical role of redox homeostasis in Shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway. Oxid Med Cell Longev, 2012 :781516<br> 23.Zhang B, Wang XQ, Li X, Ni YQ, Li HY. Aluminum uptake and disease resistance in Nicotiana rustica leaves. Ecotox Environ Safe, 2010, 73:655-663<br> |