师资队伍

张波

职称:二级教授

最高学历毕业院校及专业:兰州大学 生化与分子生物学

所属学科:药理学

电子邮件:bozhang_lzu@126.com

个人简历

研究方向

代表性论著

教学科研项目及获奖

职称 二级教授 最高学历毕业院校及专业 兰州大学 生化与分子生物学
所属学科 药理学 电子邮箱 bozhang_lzu@126.com
研究方向 地方药、民族药中药药理与新适应症。 发表论文 1.Dong S, Han J, Sun XY, Zhang B*</strong>, Wang W*, A novel 2D g-C3N4 material applied for Paraquat adsorbing and detoxifying in vitro and in vivo. Ecotox Environ Safe, 2023, 266,115594<br>
2.Luo Q, Ji XY, Zhang L, Huang X, Wang XQ, Zhang B*.Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways. Biomed  Pharmacother, 2023, 166:115346<br>
3.Wei H, Li ZX, Ji XY, Wang XQ, Zhang B*.Why do red- and yellow-colored edible herbs create warmth? A system pharmacological view of curcumin-mediated protection of mice from cold stress. J Funct Food, 2023,108:105726<br>
4.Wang QQ, Sun QR, Ji XY, Tang Y, Zhang K, Wang XQ, Li HR, Huang XZ*, Zhang B*.The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data.  J Ethnopharmcol, 2022, 303, 115990<br>
5.Zhang Y, Deng X, Zhang J, Zhang L, Akram Z, Zhang B*, Sun S*. A Potential Driver of Disseminated Intravascular Coagulation in Heat Stroke Mice: Neutrophil Extracellular Traps. Int J Environ Res Public Health. 2022, 19:12448.<br>
6.Ding Q, Luo L, Yu L, Huang SL, Wang XQ, Zhang B*,The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis, Free Radical Bio Med, 2021, 176:392-405<br>
7.Wang J, Luo L, Ding Q, Wu Z, Peng Y, Li J, Wang X, Li W, Liu G, Zhang B* and Tang Y* (2021) Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods. Front Pharmacol  2021,12:754175<br>
8.Deng YX, Zhong J, Liu ZJ, Wang XQ*, Zhang B*, Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment. J Ethnopharmcol, 2021, 265, 113385<br>
9.Zhang J, Yang ZH, Zhang SS, Xie ZZ, Han SC, Wang LX, Zhang B*, Sun SG*. Investigation of endogenous malondialdehyde through fluorescent probe MDA-6 during oxidative stress. Analytica Chimica Acta, 2020,1116, 9-15<br>
10.Chai BY, Gong FK, Chen ZH, Li ZX, Zhang B*. System prediction and validation of TCM for chronic myeloid leukemia treatment from the perspective of low-toxicity chemotherapy: a stilbene a-viniferin has a pro-apoptotic effect on K562 cells via the mitochondrial pathway. Evid-Based Comple Alt, 2020, 1986962<br>
11.Liu ZJ, Zhong J,Zhang M, Chen ZH,Wang JY, Chen HY, Wang XQ, Zhang B*.The alexipharmic mechanisms of five licorice ingredients involved in CYP450 and Nrf2 pathways in paraquat-induced mice acute lung injury. Oxid Med Cell Longev, 2019,  7283104<br>
12.Wang J Y, Chen H, Wang YY,Wang XQ, Chen H Y, Zhang M ,Tang Y*, Zhang B*. Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst biol, 2017,11:103<br>
13.Zhang B, Liu J, Ma XR, Zuo P, Ye BC, Li YC, Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors, Biosens Bioelectron, 2016, 80: 491-496<br>
14.Zhang B, Fu YX, Huang C, Zheng CL, Wu ZY et al., New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep-UK.2016, 6, 21872<br>
15.Zhang B, Wang X Q*, Chen H Y, Liu B H. Involvement of the Nrf2 Pathway in the Regulation of Pterostilbene-Induced Apoptosis in HeLa Cells via ER Stress. J Pharmacol Sci, 2014,126:216-229<br>
16.Zhang B, Xie C, Zhong J, Chen HY, Zhang HY, Wang XQ*. A549 cell proliferation inhibited by RNAi mediated silencing of the Nrf2 gene. Bio-med Mater Eng, 2014, 24: 3905-3916<br>
17.Zhang B, Chen N, Chen H, Wang Z, Zheng Q. The critical role of redox homeostasis in Shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway. Oxid Med Cell Longev, 2012 :781516<br>
18.Zhang B, Wang XQ, Li X, Ni YQ, Li HY. Aluminum uptake and disease resistance in Nicotiana rustica leaves. Ecotox Environ Safe, 2010, 73:655-663<br>
教学科研成果 第一发明人专利:<br>
1. 一种升高葡萄白藜芦醇含量的方法。2010,中国专利ZL 201010509046.8<br>
2. 一种诱导葡萄茋类物质积累的方法。2014,中国专利ZL 201210380456.6<br>
3. 一种降温组合物、功能型降温贴及其制备方法。2023,中国专利 CN 202311077406.5<br>
4. 一种复方防冻抗冻组合物及其制备方法与应用。2023,中国专利 CN 202310104751.7<br>


教学科研成果:<br>

一、教学科研项目:<br>
1、国家自然科学基金(U1603122)2017-2019,主持<br>
2、国家自然科学基金(81460566)2015-2018,主持<br>
3、国家自然科学基金(31160058)2012-2015,主持<br>
4、国家自然科学基金(30860032)2009-2011,主持<br>
5、兵团博士资金项目(2011BB018)2011-2013,主持<br>
6、兵团医药科技攻关专项(2010GG36)2010-2012,主持<br>
7、四川省天府峨眉计划(创新领军人才)2021-2025,主持<br>
8、兵团英才(第一层次)2019-2022,主持<br>
9、兵团科技创新领域中青年领军人才计划(领军人才)2018-2021,主持<br>
10、国家自然基金重点项目(U1603285),2017-2019,子课题负责<br>
11、973计划前期研究专项(2010CB535003)2011-2013,子课题负责<br>
12、科技部重大新药创制专项(2009ZX09103- 141)2009-2012,子课题负责<br>

二、获奖:<br>
1、省部级科技进步一等奖,排名3,2014<br>
2、省部级科技进步一等奖,排名2,2017<br>
3、省高校科学技术奖,排名4,2019<br>
4、省创新创业团队三等奖,排名1,2015<br>
5、Journal of Integrative Plant Biology最佳论文奖,2008<br>
6、省互联网+大学生创新创业大赛二等奖“优秀指导教师”,2019<br>
7、“全国最美家庭”荣誉称号,2020<br>

张波,博士研究生,二级教授。

学术经历:

西北大学生物化学(本科,1997-2021)

兰州大学生物化学与分子生物学(博士,2002-2007)

西北农林科技大学(访问学者,2015)

华东理工大学(访问学者,2016)

加州大学洛杉矶分校(访问学者,2019)

工作经历:

曾就职于兰州生物制品研究所第三研究室(2001),

曾任职石河子大学药学院副院长、教育部重点实验室常务副主任(2017-2021);

2021年调入成都大学药学院、四川抗菌素工业研究所,现为药理学方向学术带头人。

学术兼职:

中国药理学会“生化与分子药理专业委员会”常务委员

中国药理学会“教学与科普专业委员会”常务委员

中国药理学会“中药与天然产物药理学专业委员会”委员

中国药理学会“表观遗传学专业委员会”委员

《中草药》(中文核心期刊)青年编委

《石河子大学学报-自然科学版》(中文核心期刊)编委

人才称号:

入选四川省天府峨眉创新领军人才(2021)

新疆维吾尔自治区十三五重点学科带头人(2016)

兵团科技创新领域中青年领军人才(2018)

兵团英才第一层次入选(2019)

地方药、民族药中药药理与新适应症。

1.Dong S, Han J, Sun XY, Zhang B*, Wang W*, A novel 2D g-C3N4 material applied for Paraquat adsorbing and detoxifying in vitro and in vivo. Ecotox Environ Safe, 2023, 266,115594
2.Luo Q, Ji XY, Zhang L, Huang X, Wang XQ, Zhang B*.Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways. Biomed Pharmacother, 2023, 166:115346
3.Wei H, Li ZX, Ji XY, Wang XQ, Zhang B*.Why do red- and yellow-colored edible herbs create warmth? A system pharmacological view of curcumin-mediated protection of mice from cold stress. J Funct Food, 2023,108:105726
4.Wang QQ, Sun QR, Ji XY, Tang Y, Zhang K, Wang XQ, Li HR, Huang XZ*, Zhang B*.The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data. J Ethnopharmcol, 2022, 303, 115990
5.Zhang Y, Deng X, Zhang J, Zhang L, Akram Z, Zhang B*, Sun S*. A Potential Driver of Disseminated Intravascular Coagulation in Heat Stroke Mice: Neutrophil Extracellular Traps. Int J Environ Res Public Health. 2022, 19:12448.
6.Ding Q, Luo L, Yu L, Huang SL, Wang XQ, Zhang B*,The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis, Free Radical Bio Med, 2021, 176:392-405
7.Wang J, Luo L, Ding Q, Wu Z, Peng Y, Li J, Wang X, Li W, Liu G, Zhang B* and Tang Y* (2021) Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods. Front Pharmacol 2021,12:754175
8.Deng YX, Zhong J, Liu ZJ, Wang XQ*, Zhang B*, Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment. J Ethnopharmcol, 2021, 265, 113385
9.Zhang J, Yang ZH, Zhang SS, Xie ZZ, Han SC, Wang LX, Zhang B*, Sun SG*. Investigation of endogenous malondialdehyde through fluorescent probe MDA-6 during oxidative stress. Analytica Chimica Acta, 2020,1116, 9-15
10.Chai BY, Gong FK, Chen ZH, Li ZX, Zhang B*. System prediction and validation of TCM for chronic myeloid leukemia treatment from the perspective of low-toxicity chemotherapy: a stilbene a-viniferin has a pro-apoptotic effect on K562 cells via the mitochondrial pathway. Evid-Based Comple Alt, 2020, 1986962
11.Liu ZJ, Zhong J,Zhang M, Chen ZH,Wang JY, Chen HY, Wang XQ, Zhang B*.The alexipharmic mechanisms of five licorice ingredients involved in CYP450 and Nrf2 pathways in paraquat-induced mice acute lung injury. Oxid Med Cell Longev, 2019, 7283104
12.Wang J Y, Chen H, Wang YY,Wang XQ, Chen H Y, Zhang M ,Tang Y*, Zhang B*. Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst biol, 2017,11:103
13.Zhang B, Liu J, Ma XR, Zuo P, Ye BC, Li YC, Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors, Biosens Bioelectron, 2016, 80: 491-496
14.Zhang B, Fu YX, Huang C, Zheng CL, Wu ZY et al., New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep-UK.2016, 6, 21872
15.Zhang B, Wang X Q*, Chen H Y, Liu B H. Involvement of the Nrf2 Pathway in the Regulation of Pterostilbene-Induced Apoptosis in HeLa Cells via ER Stress. J Pharmacol Sci, 2014,126:216-229
16.Zhang B, Xie C, Zhong J, Chen HY, Zhang HY, Wang XQ*. A549 cell proliferation inhibited by RNAi mediated silencing of the Nrf2 gene. Bio-med Mater Eng, 2014, 24: 3905-3916
17.Zhang B, Chen N, Chen H, Wang Z, Zheng Q. The critical role of redox homeostasis in Shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway. Oxid Med Cell Longev, 2012 :781516
18.Zhang B, Wang XQ, Li X, Ni YQ, Li HY. Aluminum uptake and disease resistance in Nicotiana rustica leaves. Ecotox Environ Safe, 2010, 73:655-663

第一发明人专利:
1. 一种升高葡萄白藜芦醇含量的方法。2010,中国专利ZL 201010509046.8
2. 一种诱导葡萄茋类物质积累的方法。2014,中国专利ZL 201210380456.6
3. 一种降温组合物、功能型降温贴及其制备方法。2023,中国专利 CN 202311077406.5
4. 一种复方防冻抗冻组合物及其制备方法与应用。2023,中国专利 CN 202310104751.7
教学科研成果:
一、教学科研项目:
1、国家自然科学基金(U1603122)2017-2019,主持
2、国家自然科学基金(81460566)2015-2018,主持
3、国家自然科学基金(31160058)2012-2015,主持
4、国家自然科学基金(30860032)2009-2011,主持
5、兵团博士资金项目(2011BB018)2011-2013,主持
6、兵团医药科技攻关专项(2010GG36)2010-2012,主持
7、四川省天府峨眉计划(创新领军人才)2021-2025,主持
8、兵团英才(第一层次)2019-2022,主持
9、兵团科技创新领域中青年领军人才计划(领军人才)2018-2021,主持
10、国家自然基金重点项目(U1603285),2017-2019,子课题负责
11、973计划前期研究专项(2010CB535003)2011-2013,子课题负责
12、科技部重大新药创制专项(2009ZX09103- 141)2009-2012,子课题负责
二、获奖:
1、省部级科技进步一等奖,排名3,2014
2、省部级科技进步一等奖,排名2,2017
3、省高校科学技术奖,排名4,2019
4、省创新创业团队三等奖,排名1,2015
5、Journal of Integrative Plant Biology最佳论文奖,2008
6、省互联网+大学生创新创业大赛二等奖“优秀指导教师”,2019
7、“全国最美家庭”荣誉称号,2020