师资队伍

张波

职称:二级教授

最高学历毕业院校及专业:兰州大学 生化与分子生物学

所属学科:药理学

电子邮件:bozhang_lzu@126.com或 booo.zhang@utoronto.ca

个人简历

研究方向

代表性论著

教学科研项目及获奖

职称 二级教授 最高学历毕业院校及专业 兰州大学 生化与分子生物学
所属学科 药理学 电子邮箱 bozhang_lzu@126.com或 booo.zhang@utoronto.ca
研究方向 药理学:抗衰老(黑色素代谢)与环境医学防护(热射病)方向;<br>

研究平台:现有斑马鱼快速药物筛选与评价系统,细胞与分子药理相关机制研究平台,在中药民族药物质基础研究领域建立了环境应激相似性的快速筛选与靶点预测模型。<br>
标志性成果:以氧还调控为科学原理,研发出“基于氧还调控理论的MIP复合荧光组学的毒物早期预警关键技术”,在医药工业领域建立了细胞微观超灵敏快速检测装置,该技术与荧光探针标记示踪技术相结合,构建了物理、化学、生物信号转化成电信号的新型传感分析筛选平台,在临床诊断、食品安全、药品生产过程中等多家医院与企业得到了推广应用。代表成果获省级科技进步一等奖2项(2014, 2017),省高校自然科学二等奖1项(2019)。
发表论文 第一作者及通讯作者SCI代表作:<br>
1.Chen, P.; Ji, X.-Y.; Feng, J.-T.; Wang, X.-Q.; Zhang, B*. The Synergistic Mechanism of Chelidonium majus Alkaloids on Melanoma Treatment via a Multi-Strategy Insight. Molecules 2024,29:5412<br>
2.Ma SZ, Dong S, Zhou ZY, Ji XY, Zhang YY, Wang XQ, Zhang B*. The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway. J Ethnopharmacol. 2024,334:118565<br>
3.Ji XY, Feng JT, Zhou ZY, Zhang YY, Ma SZ, Wang XQ, Zhang B*. Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway. Phytomedicine. 2024,132:155853<br>
4.Dong S, Liu Z, Chen H, Ma S, Wang F, Shen H, Li H, Zhang B*. A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD. Phytomedicine. 2024,132:155664<br>
5. Zhang J, You S, Yu L, Zhang Y, Li Z, Zhao N, Zhang B*, Kang L*, Sun S*. The hysteresis damage of cold exposure on tissue and transcript levels in mice. J Therm Biol. 2024,120:103823<br>
6.Dong S, Han J, Sun XY, Zhang B*, Wang W*, A novel 2D g-C3N4 material applied for Paraquat adsorbing and detoxifying in vitro and in vivo. Ecotox Environ Safe, 2023, 266,115594<br>
7.Luo Q, Ji XY, Zhang L, Huang X, Wang XQ, Zhang B*.Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways. Biomed Pharmacother, 2023,166:115346<br>
8.Wei H, Li ZX, Ji XY, Wang XQ, Zhang B*.Why do red- and yellow-colored edible herbs create warmth? A system pharmacological view of curcumin-mediated protection of mice from cold stress. J Funct Food, 2023,108:105726<br>
9.Wang QQ, Sun QR, Ji XY, Tang Y, Zhang K, Wang XQ, Li HR, Huang XZ*, Zhang B*.The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data. J Ethnopharmcol, 2022,303,115990<br>
10.Zhang Y, Deng X, Zhang J, Zhang L, Akram Z, Zhang B*, Sun S*. A Potential Driver of Disseminated Intravascular Coagulation in Heat Stroke Mice: Neutrophil Extracellular Traps. Int J Environ Res Public Health. 2022, 19:12448.<br>
11.Ding Q, Luo L, Yu L, Huang SL, Wang XQ, Zhang B*,The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis, Free Radical Bio Med, 2021, 176:392-405<br>
12.Wang J, Luo L, Ding Q, Wu Z, Peng Y, Li J, Wang X, Li W, Liu G, Zhang B* and Tang Y* (2021) Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods. Front Pharmacol 2021,12:754175<br>
13.Deng YX, Zhong J, Liu ZJ, Wang XQ*, Zhang B*, Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment. J Ethnopharmcol, 2021, 265, 113385<br>
14.Zhang J, Yang ZH, Zhang SS, Xie ZZ, Han SC, Wang LX, Zhang B*, Sun SG*. Investigation of endogenous malondialdehyde through fluorescent probe MDA-6 during oxidative stress. Analytica Chimica Acta, 2020,1116, 9-15<br>
15.Chai BY, Gong FK, Chen ZH, Li ZX, Zhang B*. System prediction and validation of TCM for chronic myeloid leukemia treatment from the perspective of low-toxicity chemotherapy: a stilbene a-viniferin has a pro-apoptotic effect on K562 cells via the mitochondrial pathway. Evid-Based Comple Alt, 2020, 1986962<br>
16.Liu ZJ, Zhong J,Zhang M, Chen ZH,Wang JY, Chen HY, Wang XQ, Zhang B*.The alexipharmic mechanisms of five licorice ingredients involved in CYP450 and Nrf2 pathways in paraquat-induced mice acute lung injury. Oxid Med Cell Longev, 2019, 7283104<br>
17.Wang J Y, Chen H, Wang YY,Wang XQ, Chen H Y, Zhang M ,Tang Y*, Zhang B*. Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst biol, 2017,11:103<br>
18.Zhang B, Liu J, Ma XR, Zuo P, Ye BC, Li YC, Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors, Biosens Bioelectron, 2016, 80: 491-496<br>
19.Zhang B, Fu YX, Huang C, Zheng CL, Wu ZY et al., New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep-UK.2016, 6, 21872<br>
20.Zhang B, Wang X Q*, Chen H Y, Liu B H. Involvement of the Nrf2 Pathway in the Regulation of Pterostilbene-Induced Apoptosis in HeLa Cells via ER Stress. J Pharmacol Sci, 2014,126:216-229
21.Zhang B, Xie C, Zhong J, Chen HY, Zhang HY, Wang XQ*. A549 cell proliferation inhibited by RNAi mediated silencing of the Nrf2 gene. Bio-med Mater Eng, 2014, 24: 3905-3916<br>
22.Zhang B, Chen N, Chen H, Wang Z, Zheng Q. The critical role of redox homeostasis in Shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway. Oxid Med Cell Longev, 2012 :781516<br>
23.Zhang B, Wang XQ, Li X, Ni YQ, Li HY. Aluminum uptake and disease resistance in Nicotiana rustica leaves. Ecotox Environ Safe, 2010, 73:655-663<br>
教学科研成果 教学科研成果(省级及以上):<br>
教学科研项目:<br>
1、国家自然科学基金(U1603122)2017-2019,主持<br>
2、国家自然科学基金(81460566)2015-2018,主持<br>
3、国家自然科学基金(31160058)2012-2015,主持<br>
4、国家自然科学基金(30860032)2009-2011,主持<br>
5、兵团博士资金项目(2011BB018)2011-2013,主持<br>
6、兵团医药科技攻关专项(2010GG36)2010-2012,主持<br>
7、四川省天府峨眉计划-创新领军人才(1811)2021-2025,主持<br>
8、四川省自然科学基金(25NSFSC2577)2025-2025,主持<br>
9、兵团英才(第一层次)2019-2022,主持<br>
10、兵团科技创新领域中青年领军人才计划(领军人才)2018-2021,主持<br>
11、国家自然基金重点项目(U1603285),2017-2019,子课题负责<br>
12、973计划前期研究专项(2010CB535003)2011-2013,子课题负责<br>
13、科技部重大新药创制专项(2009ZX09103- 141)2009-2012,子课题负责<br>
14、国家留学基金委青年骨干教师出国研修项目(202210640001)2022-2024,主持<br>
第一发明人专利:<br>
1. 一种升高葡萄白藜芦醇含量的方法。2010,中国专利ZL 201010509046.8<br>
2. 一种诱导葡萄茋类物质积累的方法。2014,中国专利ZL 201210380456.6<br>
3. 一种降温组合物、功能型降温贴及其制备方法。2023,中国专利 CN 202311077406.5<br>4. 4. 一种复方防冻抗冻组合物及其制备方法与应用。2023,中国专利 CN 202310104751.7<br>

主编出版专著3部:<br>
1.《急症重病综合治疗》-新疆生产建设兵团出版社,ISBN 978-7-80756-701-1,2013<br>
2.《现代医学科学理论研究与实践》-吉林大学出版社,ISBN 978-7-5677-4139-3,2015<br>
3.《现代分子生物学反应及实验技术研究》-吉林大学出版社,ISBN 978-7-5677-6773-7,2016<br>

获奖:<br>
1、省部级科技进步一等奖,排名3,2014<br>
2、省部级科技进步一等奖,排名2,2017<br>
3、省高校科学技术奖,排名4,2019<br>
4、省创新创业团队三等奖,排名1,2015<br>
5、Journal of Integrative Plant Biology最佳论文奖,2008<br>
6、省互联网+大学生创新创业大赛二等奖“优秀指导教师”,2019<br>
7、“全国最美家庭”荣誉称号,2020<br>

张波,博士研究生,二级教授(药理学),博士生导师(生物化学与分子生物学)。

学术经历:

西北大学生物化学(本科,1997-2021)

兰州大学生物化学与分子生物学(博士,2002-2007)

西北农林科技大学(访问学者,2015)

华东理工大学(访问学者,2016)

加州大学洛杉矶分校(访问学者,2019)

多伦多大学(访问学者,2024-2025)

工作经历:

曾就职于兰州生物制品研究所第三研究室(2001),

曾任职石河子大学药学院副院长、教育部重点实验室常务副主任(2017-2021);

2021年调入成都大学药学院、四川抗菌素工业研究所,现为药理学方向学术带头人。

学术兼职:

中国药理学会“生化与分子药理专业委员会”常务委员

中国药理学会“教学与科普专业委员会”常务委员

中国药理学会“中药与天然产物药理学专业委员会”委员

中国药理学会“表观遗传学专业委员会”委员

《中草药》(中文核心期刊)青年编委

人才称号:

入选四川省天府峨眉创新领军人才(2021)

新疆维吾尔自治区十三五重点学科带头人(2016)

兵团科技创新领域中青年领军人才(2018)

兵团英才第一层次入选(2019)

药理学:抗衰老(黑色素代谢)与环境医学防护(热射病)方向;
研究平台:现有斑马鱼快速药物筛选与评价系统,细胞与分子药理相关机制研究平台,在中药民族药物质基础研究领域建立了环境应激相似性的快速筛选与靶点预测模型。
标志性成果:以氧还调控为科学原理,研发出“基于氧还调控理论的MIP复合荧光组学的毒物早期预警关键技术”,在医药工业领域建立了细胞微观超灵敏快速检测装置,该技术与荧光探针标记示踪技术相结合,构建了物理、化学、生物信号转化成电信号的新型传感分析筛选平台,在临床诊断、食品安全、药品生产过程中等多家医院与企业得到了推广应用。代表成果获省级科技进步一等奖2项(2014, 2017),省高校自然科学二等奖1项(2019)。

第一作者及通讯作者SCI代表作:
1.Chen, P.; Ji, X.-Y.; Feng, J.-T.; Wang, X.-Q.; Zhang, B*. The Synergistic Mechanism of Chelidonium majus Alkaloids on Melanoma Treatment via a Multi-Strategy Insight. Molecules 2024,29:5412
2.Ma SZ, Dong S, Zhou ZY, Ji XY, Zhang YY, Wang XQ, Zhang B*. The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway. J Ethnopharmacol. 2024,334:118565
3.Ji XY, Feng JT, Zhou ZY, Zhang YY, Ma SZ, Wang XQ, Zhang B*. Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway. Phytomedicine. 2024,132:155853
4.Dong S, Liu Z, Chen H, Ma S, Wang F, Shen H, Li H, Zhang B*. A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD. Phytomedicine. 2024,132:155664
5. Zhang J, You S, Yu L, Zhang Y, Li Z, Zhao N, Zhang B*, Kang L*, Sun S*. The hysteresis damage of cold exposure on tissue and transcript levels in mice. J Therm Biol. 2024,120:103823
6.Dong S, Han J, Sun XY, Zhang B*, Wang W*, A novel 2D g-C3N4 material applied for Paraquat adsorbing and detoxifying in vitro and in vivo. Ecotox Environ Safe, 2023, 266,115594
7.Luo Q, Ji XY, Zhang L, Huang X, Wang XQ, Zhang B*.Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways. Biomed Pharmacother, 2023,166:115346
8.Wei H, Li ZX, Ji XY, Wang XQ, Zhang B*.Why do red- and yellow-colored edible herbs create warmth? A system pharmacological view of curcumin-mediated protection of mice from cold stress. J Funct Food, 2023,108:105726
9.Wang QQ, Sun QR, Ji XY, Tang Y, Zhang K, Wang XQ, Li HR, Huang XZ*, Zhang B*.The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data. J Ethnopharmcol, 2022,303,115990
10.Zhang Y, Deng X, Zhang J, Zhang L, Akram Z, Zhang B*, Sun S*. A Potential Driver of Disseminated Intravascular Coagulation in Heat Stroke Mice: Neutrophil Extracellular Traps. Int J Environ Res Public Health. 2022, 19:12448.
11.Ding Q, Luo L, Yu L, Huang SL, Wang XQ, Zhang B*,The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis, Free Radical Bio Med, 2021, 176:392-405
12.Wang J, Luo L, Ding Q, Wu Z, Peng Y, Li J, Wang X, Li W, Liu G, Zhang B* and Tang Y* (2021) Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods. Front Pharmacol 2021,12:754175
13.Deng YX, Zhong J, Liu ZJ, Wang XQ*, Zhang B*, Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment. J Ethnopharmcol, 2021, 265, 113385
14.Zhang J, Yang ZH, Zhang SS, Xie ZZ, Han SC, Wang LX, Zhang B*, Sun SG*. Investigation of endogenous malondialdehyde through fluorescent probe MDA-6 during oxidative stress. Analytica Chimica Acta, 2020,1116, 9-15
15.Chai BY, Gong FK, Chen ZH, Li ZX, Zhang B*. System prediction and validation of TCM for chronic myeloid leukemia treatment from the perspective of low-toxicity chemotherapy: a stilbene a-viniferin has a pro-apoptotic effect on K562 cells via the mitochondrial pathway. Evid-Based Comple Alt, 2020, 1986962
16.Liu ZJ, Zhong J,Zhang M, Chen ZH,Wang JY, Chen HY, Wang XQ, Zhang B*.The alexipharmic mechanisms of five licorice ingredients involved in CYP450 and Nrf2 pathways in paraquat-induced mice acute lung injury. Oxid Med Cell Longev, 2019, 7283104
17.Wang J Y, Chen H, Wang YY,Wang XQ, Chen H Y, Zhang M ,Tang Y*, Zhang B*. Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst biol, 2017,11:103
18.Zhang B, Liu J, Ma XR, Zuo P, Ye BC, Li YC, Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors, Biosens Bioelectron, 2016, 80: 491-496
19.Zhang B, Fu YX, Huang C, Zheng CL, Wu ZY et al., New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep-UK.2016, 6, 21872
20.Zhang B, Wang X Q*, Chen H Y, Liu B H. Involvement of the Nrf2 Pathway in the Regulation of Pterostilbene-Induced Apoptosis in HeLa Cells via ER Stress. J Pharmacol Sci, 2014,126:216-229 21.Zhang B, Xie C, Zhong J, Chen HY, Zhang HY, Wang XQ*. A549 cell proliferation inhibited by RNAi mediated silencing of the Nrf2 gene. Bio-med Mater Eng, 2014, 24: 3905-3916
22.Zhang B, Chen N, Chen H, Wang Z, Zheng Q. The critical role of redox homeostasis in Shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway. Oxid Med Cell Longev, 2012 :781516
23.Zhang B, Wang XQ, Li X, Ni YQ, Li HY. Aluminum uptake and disease resistance in Nicotiana rustica leaves. Ecotox Environ Safe, 2010, 73:655-663

教学科研成果(省级及以上):
教学科研项目:
1、国家自然科学基金(U1603122)2017-2019,主持
2、国家自然科学基金(81460566)2015-2018,主持
3、国家自然科学基金(31160058)2012-2015,主持
4、国家自然科学基金(30860032)2009-2011,主持
5、兵团博士资金项目(2011BB018)2011-2013,主持
6、兵团医药科技攻关专项(2010GG36)2010-2012,主持
7、四川省天府峨眉计划-创新领军人才(1811)2021-2025,主持
8、四川省自然科学基金(25NSFSC2577)2025-2025,主持
9、兵团英才(第一层次)2019-2022,主持
10、兵团科技创新领域中青年领军人才计划(领军人才)2018-2021,主持
11、国家自然基金重点项目(U1603285),2017-2019,子课题负责
12、973计划前期研究专项(2010CB535003)2011-2013,子课题负责
13、科技部重大新药创制专项(2009ZX09103- 141)2009-2012,子课题负责
14、国家留学基金委青年骨干教师出国研修项目(202210640001)2022-2024,主持
第一发明人专利:
1. 一种升高葡萄白藜芦醇含量的方法。2010,中国专利ZL 201010509046.8
2. 一种诱导葡萄茋类物质积累的方法。2014,中国专利ZL 201210380456.6
3. 一种降温组合物、功能型降温贴及其制备方法。2023,中国专利 CN 202311077406.5
4. 4. 一种复方防冻抗冻组合物及其制备方法与应用。2023,中国专利 CN 202310104751.7
主编出版专著3部:
1.《急症重病综合治疗》-新疆生产建设兵团出版社,ISBN 978-7-80756-701-1,2013
2.《现代医学科学理论研究与实践》-吉林大学出版社,ISBN 978-7-5677-4139-3,2015
3.《现代分子生物学反应及实验技术研究》-吉林大学出版社,ISBN 978-7-5677-6773-7,2016
获奖:
1、省部级科技进步一等奖,排名3,2014
2、省部级科技进步一等奖,排名2,2017
3、省高校科学技术奖,排名4,2019
4、省创新创业团队三等奖,排名1,2015
5、Journal of Integrative Plant Biology最佳论文奖,2008
6、省互联网+大学生创新创业大赛二等奖“优秀指导教师”,2019
7、“全国最美家庭”荣誉称号,2020