采用化学生物学的原理与方法，建立多种体外及细胞药物筛选模型，发现能够调控乙二醛酶系统、炎症通路、肿瘤细胞凋亡等的化学小分子，研究其构效关系，以活性小分子为探针研究其作用机制，以期发现新的信号调控机制以及具有诊疗作用的药物前体。

1.Ting Peng#, Yujiao He#, Tao Wang#, Jialing Yu#, Xiaofang Ma#, Zongyuan Zhou, Yuwen Sheng, Lingyu Li, Huipan Peng, Sheng Li, Jiawei Zou, Yi Yuan, Yongyun Zhao, Hailong Shi, Fu Li, Wanli Liu, Kaifeng Hu*, Xiaoxia Lu*, Guolin Zhang*, and Fei Wang*. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP–Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. Journal of Medicinal Chemistry, 2022, 65(16), 11010-11033.
2.Hongbo Dong, Min Wu, Ying Li, Lan Lu, Jialan Qin, Yujiao He,* and Zheng Shi*. Total syntheses and anti-inflammatory evaluations of pongamosides A–C, natural furanoflavonoid glucosides from fruit of Pongamia pinnata (L.) Pierre. Journal of Natural Products, 2022, 85(4), 1118-1127.
3.Hongbo Dong, Min Wu, Weihong Du, Mingwei Shong, Yujiao He and Yuchi Wang (2022). First asymmetric total synthesis of Millpuline B. Synthetic Communications, 2022, 52(1), 79-84.
4.Yujiao He, Maolin Huang, Chunyan Tang, Yan Yue, Xiao Liu, Zhebin Zheng, Hongbo Dong*, Deming Liu*. Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels. Virus Research, 2021, 298, 198404.
5.Hongbo Dong, Min Wu, Yingying Wang, Weihong Du, Yujiao He,* and Zheng Shi*. Total syntheses and anti-inflammatory activities of syringin and its natural analogues. Journal of Natural Products, 2021, 84(11), 2866-2874.
6.Yujiao He, Xiao Liu, Maolin Huang, Zheng Wei, Mengyu Zhang, Mengtao He, Zhebin Zheng, Hongbo Dong*, Deming Liu*. (2021). Oleanolic acid inhibits the migration and invasion of hepatocellular carcinoma cells by promoting microRNA-122 expression. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2021, 76(9), 422-427.
7.Guangya Xu, Min Wu, Zhongquan Yao, Hongbin Lou, Weihong Du, Mingwei Song, Yujiao He and Hongbo Dong. First total syntheses of four natural bioactive glucosides. Synthetic Communications, 2021, 51(8), 1266-1271.
8.Hongbo Dong*, Weihong Du, Zhongquan Yao, Min Wu, Hongbing Luo, Yujiao He, Shenghua Cao. First total syntheses of two natural glycosides. Carbohydrate Research, 2021, 499, 108200.
9.Yujiao He, Chunyan Zhou, Maolin Huang, Chunyan Tang, Xiao Liu, Yan Yue, Qingchun Diao*, Zhebin Zheng*, Deming Liu*. Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators. Biomedicine & Pharmacotherapy, 2020, 131, 110663.
10.Orawan Wonganan, Yujiao He, Xiaofei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology, 2017, 336, 31-39.
11.Yujiao He, Junmei Huang, Ping Wang, Xiaofei Shen, Sheng Li, Lijuan Yang, Wanli Liu, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*. Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget, 2016, 7(4), 4664.
12.Sheng Li#, Li-juan Yang#, Ping Wang, Yujiao He, Junmei Huang, Hanwei Liu, Xiaofei Shen and Fei Wang. Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation. Food & nutrition research, 2016, 60(1), 31288.
13.WeiHua Wang, Yin Nian, YuJiao He, Luo-Sheng Wan, Ni-Man Bao, Guo-Lei Zhu, Fei Wang, Ming-hua Qiu. New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia. Tetrahedron, 2015, 71(42), 8018-8025.
14.Zhengfu Tai#, Yuan Lin#, Yujiao He, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, FeiWang*. (2014). Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. Cellular Signalling, 2014, 26(3), 619-628.

主持科研项目：
1. 国家自然科学基金青年科学基金项目，2018.1-2020.12，主持
2. 四川省教育厅科研项目，2018.1-2019.12，主持
3. 抗生素研究与再评价四川省重点实验室开放课题（2项），主持
4. 四川省药物制剂及装备工程技术研究中心开放课题，2021.10-2022.10, 主持
5. 药食同源植物资源开发四川省高校重点实验室开放课题，2017.7-2019.12，主持
6. 成都大学引进人才启动项目, 2016.10-2021.10，主持
参与教学获奖： 1.四川省一流本科课程（药理学），2022，参与
2.成都大学青年教师教学竞赛校级优秀奖，2021