师资队伍

吴笛

职称:特聘研究员

最高学历毕业院校及专业:四川大学 应用化学

所属学科:药剂学

电子邮件:diwulab@163.com

个人简历

研究方向

代表性论著

教学科研项目及获奖

职称 特聘研究员 最高学历毕业院校及专业 四川大学 应用化学
所属学科 药剂学 电子邮箱 diwulab@163.com
研究方向 药物分析与递送,蛋白质互作网络 发表论文 2024年<br>
1.Zhang Jing, Tang Lan, Hu Xia, Zeng Zhen, Wu Wen, Geng Fang, Li Hui, Wu Di*. Evaluation of the binding affinity and antioxidant activity of phlorizin to pepsin and trypsin[J]. Food Science and Human Wellness 13 (2024) 392-400. (中科院一区,IF=7.0) <br>
2023年 <br>
2.Li Mohan, Zhou Dian, Wu Di*, Hu Xia, Hu Jie, Geng Fang, Cheng Lei. Comparative analysis of the interaction between alpha-lactalbumin and two edible azo colorants equipped with different sulfonyl group numbers[J]. Food Chemistry, 2023, 416: 135826. (中科院一区TOP期刊, IF=8.8)<br>
3.Li Mohan, Zhou Dian, Li Yuanqiao, Li Qinhong, Song Yali*, Geng Fang, Wu Di*. Aggregation studies of alpha-lactalbumin induced by edible azo dyes with different sulfonyl group numbers: A comparative study[J]. International Journal of Biological Macromolecules 253 (2023) 127374. (中科院一区TOP期刊, IF=8.2)<br>
4.Dian Zhou, Mohan Li, Qinhong Li, Fang Geng, Shugang Li, Di Wu*. Enhancement of liposomal properties of thyme essential oil using lysozyme modification: Physicochemical, storage, and antibacterial properties. Food Chemistry: X 20 (2023) 101057. (中科院一区TOP期刊, IF=6.1)<br>
5.Wu Di*, Hu Xia, Cai Zhangyu, Zhang Jing, Geng Fang, Li Hui. Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin[J]. Food &Function 14 (2023) 6422-6431. (中科院一区,IF=6.1)<br>
6.Li Yuanqiao, Li Mohan, Li Qinhong, Geng Fang, Wang Qingling, Gan Na, Li Shugang, Wu Di*. Revealing the Potential of Theaflavin to Reduce Egg Allergenicity at the Molecular Level: A Study of the Binding Affinity of Theaflavin to Egg White Lysozyme. Food and Bioprocess Technology (中科院二区,IF=5.6)<br>
7.Zhang Jing, Song Yali, Hu Xia, Zeng Zhen, Hu Jie, Zeng Tingting, Geng Fang, Wu Di*. Nanoparticles loaded with phlorizin fabricate a fortified yogurt with antioxidant potential[J]. Food Bioscience 54 (2023) 102849. (中科院二区, IF=5.2)<br>
8.Wu Wen, Hu Xia, Zeng Zhen, Wu Di*, Li Hanmei, Li Hui. Characterization of the Binding Properties of Sorafenib to c-MYC G-Quadruplexes: Evidence for Screening Potential Ligands[J]. The Journal of Physical Chemistry B, 2023, 127(4): 874-883. (中科院二区,IF=3.3)<br>
9.Zeng Zhen, Wu Di*, Tang Lan, Hu Xia, Zhang Jing, Geng Fang. Exploring the binding effects and inhibiting mechanism of hyperoside to lipase using multi-spectroscopic approaches, isothermal titration calorimetry, inhibition kinetics and molecular dynamics[J]. RSC Advances, 2023, 13: 6507. (中科院三区,IF=3.9)<br>
2022年<br>
10.Wu Di*, Tang Lan, Zeng Zhen, Zhang Jing, Hu Xia, Pan Qingqing, Geng Fang, Li Hui. Delivery of hyperoside by using a soybean protein isolated-soy soluble polysaccharide nanocomplex: Fabrication, characterization, and in vitro release properties, Food Chemistry, 2022, 386:132837. (中科院一区TOP期刊, IF=8.8)<br>
11.Hu Xia, Wu Di*, Tang Lan, Zhang Jing, Zeng Zhen, Geng Fang, Li Hui. Binding mechanism and antioxidant activity of piperine to hemoglobin, Food Chemistry, 2022, 394:133558.(中科院一区TOP期刊, IF=8.8)<br>
12.Hu Xia, Zeng Zhen, Zhang Jing, Wu Di*, Li Hui, Geng Fang. Molecular dynamics simulation of the interaction of food proteins with small molecules[J]. Food Chemistry, 2023, 405:134824. (中科院一区TOP期刊, IF=8.8)<br>
13.Wu Di*, Duan Ran, Tang Lan, Zhou Dian, Zeng Zhen, Wu Wen, Hu Jie, Sun Qiaomei. In-vitro binding analysis and inhibitory effect of capsaicin on lipase, LWT-food science and technology ,2022, 154.(中科院一区TOP期刊,IF=6.0)<br>
14.Di Wu*, Wu Wen, Tang Lan, Hu Xia, Zhang Jing, Li Hanmei, Li Hui. Simulation-guided relationships and interaction characteristics of human CtBP1 in complex with protocatechualdehyde, Journal of Molecular Liquids, 2022, 360:119507.(中科院二区,IF=6.0)<br>
15.Hu Jie, Wu Di*, Pan Qingqing, Li Hanmei, Zhang Jing, Geng Fang. Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine, ACS Applied Nano Materials, 2022, 5(10), 14171–14190. (中科院二区,IF=5.9)<br>
16.Jie Hu , Xia Hu, Zhen Zeng, Jing Zhang, Mohan Li, Fang Geng, Di Wu*. Interaction between a photoisomerizable azobenzene compound and alpha-lactalbumin: Spectroscopic and computational simulation studies[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 301 (2023) 122965. (中科院二区,IF=4.4)<br>
17.Tang Lan, Hu Jie, Mei Sen, Wu Di*, Zhang Jing, Wu Wen, Li Hanmei, Li Hui. Comparative analysis of the interaction between azobenzene di-maleimide and human serum albumin/lysozyme, Journal of Molecular Structure,2022,1252.(中科院二区,IF=3.8)<br>
2021年<br>
18.Wu Di*, Tang Lan, Duan Ran, Hu Xia, Geng Fang, Zhang Yin, Peng Lianxin, Li Hui. Interaction mechanisms and structure-affinity relationships between hyperoside and soybean β-conglycinin and glycinin, Food Chemistry, 2021,347:129052.(中科院一区TOP期刊,IF=8.8)<br>
19.Wu Di*, Duan Ran, Tang Lang, Hu Xia, Geng Fang, Sun Qiaomei, Zhang Yin, Li Hui. Binding mechanism and functional evaluation of quercetin 3-rhamnoside on lipase, Food Chemistry, 2021, 359:129960. (中科院一区TOP期刊,IF=8.8)<br>
2020年<br>
20.Wu Di*, Mei Sen, Duan Ran, Geng Fang, Wu Wanxia, Li Xiang, Cheng Lei, Wang Chengtao. How black tea pigment theaflavin dyes chicken eggs: Binding affinity study of theaflavin with ovalbumin, Food Chemistry, 2020, 303:125407.(中科院一区TOP期刊,IF=8.8)<br>
21.Wu Di, Huang Sheng*.Transmission success probability analysis of vehicle users with mobile relays under mobility models, Science China Information Sciences, 2020, 63(6).(中科院二区,IF=8.8)<br>
22.Duan Ran, Wu Di*, Tang Lan, Hu Xia, Cheng Lei, Yang Hongqin, Li Hanmei, Geng Fang. Interactions of thecisandtransstates of an azobenzene photoswitch with lysozyme induced by red and blue light, Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2020, 229: 117965.(中科院二区,IF=4.4)<br>
2019年<br>
23.Wu Di*, Duan Ran, Geng Fang, Hu Xia, Gan Na, Li Hui. Comparative analysis of the interaction of mono-, dis-, and tris-azo food dyes with egg white lysozyme: A combined spectroscopic and computational simulation approach, Food Chemistry, 2019, 284: 180-7.(中科院一区TOP期刊,IF=8.8)<br>
24.Wu Di*, Wang Jinqiu, Liu Dayu, Zhang Yin, Hu Xia. Computational and spectroscopic analysis of interaction between food colorant citrus red 2 and human serum albumin, Scientific Reports,2019,9(1):1615.(中科院二区,IF=4.6)<br>
25.Wu Di*, Liu Dayu, Zhang Yin, Zhang Zhen, Li Hui. Unravelling the binding mechanism of benproperine with human serum albumin: A docking,fluorometric, and thermodynamic approach, European Journal of Medicinal Chemistry,2018, 146: 245-50. (中科院一区TOP期刊,IF=6.7)<br>
教学科研成果 纵向课题:<br>
1. 国家自科基金青年基金项目:基于红光驱动的偶氮苯衍生物分子开关光调控蛋溶菌酶构象的研究(21808020,30万,2019-2021),主持<br>
2. 国家自科基金地区基金项目:蛋白质磷酸化修饰介导新疆多浪羊肉冷却贮藏品质变化的分子机制 (32360604,32万,2024-2027),联合主持<br>
3. 四川省科技厅科技计划应用基础面上项目:基于偶氮类食品着色剂光调控α-螺旋多肽构象的可行性研究及其应用(2018JY0151,10万,2018-2019),主持<br>
4. 北京市食品添加剂工程技术研究中心开放基金:基于偶氮色素光控多肽片段(2019年,4.5万,2019-2020),主持<br>
5. 农业部杂粮加工重点实验室开放基金:藜麦皂苷与功能性蛋白质的相互作用机制研究及功效评价(2018CC16,2万,2019-2020),主持<br>
6. 肉类加工四川省重点实验室开放基金:肉制品防腐剂叔丁基羟基茴香醚及其代谢产物与血清白蛋白的相互作用研究(19-R-01,2019-2020)<br>
横向课题:<br>
1. 产学研项目,四川大学华西医院,16万,主持;<br>
2. 产学研项目,成都中医药大学,3.4万,主持;<br>
3. 高层次人才培育经费,2020-2025,50万,主持。<br>

吴笛,博士,特聘研究员。

学术兼职:四川省科技青年联合会理事

学术经历:

2020.06—至今,成都大学,特聘研究员;

2017.07—2020.05,成都大学,副研究员

2015.08—2016.09,加拿大多伦多大学,访问学者

2012.09—2017.07,四川大学,应用化学,工学博士(硕博连读)

2008.09—2012.07,四川大学,制药工程,工学学士

获奖或荣誉称号:成都大学创新人才培育荣誉导师

药物分析与递送,蛋白质互作网络

2024年
1.Zhang Jing, Tang Lan, Hu Xia, Zeng Zhen, Wu Wen, Geng Fang, Li Hui, Wu Di*. Evaluation of the binding affinity and antioxidant activity of phlorizin to pepsin and trypsin[J]. Food Science and Human Wellness 13 (2024) 392-400. (中科院一区,IF=7.0)
2023年
2.Li Mohan, Zhou Dian, Wu Di*, Hu Xia, Hu Jie, Geng Fang, Cheng Lei. Comparative analysis of the interaction between alpha-lactalbumin and two edible azo colorants equipped with different sulfonyl group numbers[J]. Food Chemistry, 2023, 416: 135826. (中科院一区TOP期刊, IF=8.8)
3.Li Mohan, Zhou Dian, Li Yuanqiao, Li Qinhong, Song Yali*, Geng Fang, Wu Di*. Aggregation studies of alpha-lactalbumin induced by edible azo dyes with different sulfonyl group numbers: A comparative study[J]. International Journal of Biological Macromolecules 253 (2023) 127374. (中科院一区TOP期刊, IF=8.2)
4.Dian Zhou, Mohan Li, Qinhong Li, Fang Geng, Shugang Li, Di Wu*. Enhancement of liposomal properties of thyme essential oil using lysozyme modification: Physicochemical, storage, and antibacterial properties. Food Chemistry: X 20 (2023) 101057. (中科院一区TOP期刊, IF=6.1)
5.Wu Di*, Hu Xia, Cai Zhangyu, Zhang Jing, Geng Fang, Li Hui. Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin[J]. Food &Function 14 (2023) 6422-6431. (中科院一区,IF=6.1)
6.Li Yuanqiao, Li Mohan, Li Qinhong, Geng Fang, Wang Qingling, Gan Na, Li Shugang, Wu Di*. Revealing the Potential of Theaflavin to Reduce Egg Allergenicity at the Molecular Level: A Study of the Binding Affinity of Theaflavin to Egg White Lysozyme. Food and Bioprocess Technology (中科院二区,IF=5.6)
7.Zhang Jing, Song Yali, Hu Xia, Zeng Zhen, Hu Jie, Zeng Tingting, Geng Fang, Wu Di*. Nanoparticles loaded with phlorizin fabricate a fortified yogurt with antioxidant potential[J]. Food Bioscience 54 (2023) 102849. (中科院二区, IF=5.2)
8.Wu Wen, Hu Xia, Zeng Zhen, Wu Di*, Li Hanmei, Li Hui. Characterization of the Binding Properties of Sorafenib to c-MYC G-Quadruplexes: Evidence for Screening Potential Ligands[J]. The Journal of Physical Chemistry B, 2023, 127(4): 874-883. (中科院二区,IF=3.3)
9.Zeng Zhen, Wu Di*, Tang Lan, Hu Xia, Zhang Jing, Geng Fang. Exploring the binding effects and inhibiting mechanism of hyperoside to lipase using multi-spectroscopic approaches, isothermal titration calorimetry, inhibition kinetics and molecular dynamics[J]. RSC Advances, 2023, 13: 6507. (中科院三区,IF=3.9)
2022年
10.Wu Di*, Tang Lan, Zeng Zhen, Zhang Jing, Hu Xia, Pan Qingqing, Geng Fang, Li Hui. Delivery of hyperoside by using a soybean protein isolated-soy soluble polysaccharide nanocomplex: Fabrication, characterization, and in vitro release properties, Food Chemistry, 2022, 386:132837. (中科院一区TOP期刊, IF=8.8)
11.Hu Xia, Wu Di*, Tang Lan, Zhang Jing, Zeng Zhen, Geng Fang, Li Hui. Binding mechanism and antioxidant activity of piperine to hemoglobin, Food Chemistry, 2022, 394:133558.(中科院一区TOP期刊, IF=8.8)
12.Hu Xia, Zeng Zhen, Zhang Jing, Wu Di*, Li Hui, Geng Fang. Molecular dynamics simulation of the interaction of food proteins with small molecules[J]. Food Chemistry, 2023, 405:134824. (中科院一区TOP期刊, IF=8.8)
13.Wu Di*, Duan Ran, Tang Lan, Zhou Dian, Zeng Zhen, Wu Wen, Hu Jie, Sun Qiaomei. In-vitro binding analysis and inhibitory effect of capsaicin on lipase, LWT-food science and technology ,2022, 154.(中科院一区TOP期刊,IF=6.0)
14.Di Wu*, Wu Wen, Tang Lan, Hu Xia, Zhang Jing, Li Hanmei, Li Hui. Simulation-guided relationships and interaction characteristics of human CtBP1 in complex with protocatechualdehyde, Journal of Molecular Liquids, 2022, 360:119507.(中科院二区,IF=6.0)
15.Hu Jie, Wu Di*, Pan Qingqing, Li Hanmei, Zhang Jing, Geng Fang. Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine, ACS Applied Nano Materials, 2022, 5(10), 14171–14190. (中科院二区,IF=5.9)
16.Jie Hu , Xia Hu, Zhen Zeng, Jing Zhang, Mohan Li, Fang Geng, Di Wu*. Interaction between a photoisomerizable azobenzene compound and alpha-lactalbumin: Spectroscopic and computational simulation studies[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 301 (2023) 122965. (中科院二区,IF=4.4)
17.Tang Lan, Hu Jie, Mei Sen, Wu Di*, Zhang Jing, Wu Wen, Li Hanmei, Li Hui. Comparative analysis of the interaction between azobenzene di-maleimide and human serum albumin/lysozyme, Journal of Molecular Structure,2022,1252.(中科院二区,IF=3.8)
2021年
18.Wu Di*, Tang Lan, Duan Ran, Hu Xia, Geng Fang, Zhang Yin, Peng Lianxin, Li Hui. Interaction mechanisms and structure-affinity relationships between hyperoside and soybean β-conglycinin and glycinin, Food Chemistry, 2021,347:129052.(中科院一区TOP期刊,IF=8.8)
19.Wu Di*, Duan Ran, Tang Lang, Hu Xia, Geng Fang, Sun Qiaomei, Zhang Yin, Li Hui. Binding mechanism and functional evaluation of quercetin 3-rhamnoside on lipase, Food Chemistry, 2021, 359:129960. (中科院一区TOP期刊,IF=8.8)
2020年
20.Wu Di*, Mei Sen, Duan Ran, Geng Fang, Wu Wanxia, Li Xiang, Cheng Lei, Wang Chengtao. How black tea pigment theaflavin dyes chicken eggs: Binding affinity study of theaflavin with ovalbumin, Food Chemistry, 2020, 303:125407.(中科院一区TOP期刊,IF=8.8)
21.Wu Di, Huang Sheng*.Transmission success probability analysis of vehicle users with mobile relays under mobility models, Science China Information Sciences, 2020, 63(6).(中科院二区,IF=8.8)
22.Duan Ran, Wu Di*, Tang Lan, Hu Xia, Cheng Lei, Yang Hongqin, Li Hanmei, Geng Fang. Interactions of thecisandtransstates of an azobenzene photoswitch with lysozyme induced by red and blue light, Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2020, 229: 117965.(中科院二区,IF=4.4)
2019年
23.Wu Di*, Duan Ran, Geng Fang, Hu Xia, Gan Na, Li Hui. Comparative analysis of the interaction of mono-, dis-, and tris-azo food dyes with egg white lysozyme: A combined spectroscopic and computational simulation approach, Food Chemistry, 2019, 284: 180-7.(中科院一区TOP期刊,IF=8.8)
24.Wu Di*, Wang Jinqiu, Liu Dayu, Zhang Yin, Hu Xia. Computational and spectroscopic analysis of interaction between food colorant citrus red 2 and human serum albumin, Scientific Reports,2019,9(1):1615.(中科院二区,IF=4.6)
25.Wu Di*, Liu Dayu, Zhang Yin, Zhang Zhen, Li Hui. Unravelling the binding mechanism of benproperine with human serum albumin: A docking,fluorometric, and thermodynamic approach, European Journal of Medicinal Chemistry,2018, 146: 245-50. (中科院一区TOP期刊,IF=6.7)

纵向课题:
1. 国家自科基金青年基金项目:基于红光驱动的偶氮苯衍生物分子开关光调控蛋溶菌酶构象的研究(21808020,30万,2019-2021),主持
2. 国家自科基金地区基金项目:蛋白质磷酸化修饰介导新疆多浪羊肉冷却贮藏品质变化的分子机制 (32360604,32万,2024-2027),联合主持
3. 四川省科技厅科技计划应用基础面上项目:基于偶氮类食品着色剂光调控α-螺旋多肽构象的可行性研究及其应用(2018JY0151,10万,2018-2019),主持
4. 北京市食品添加剂工程技术研究中心开放基金:基于偶氮色素光控多肽片段(2019年,4.5万,2019-2020),主持
5. 农业部杂粮加工重点实验室开放基金:藜麦皂苷与功能性蛋白质的相互作用机制研究及功效评价(2018CC16,2万,2019-2020),主持
6. 肉类加工四川省重点实验室开放基金:肉制品防腐剂叔丁基羟基茴香醚及其代谢产物与血清白蛋白的相互作用研究(19-R-01,2019-2020)
横向课题:
1. 产学研项目,四川大学华西医院,16万,主持;
2. 产学研项目,成都中医药大学,3.4万,主持;
3. 高层次人才培育经费,2020-2025,50万,主持。