主要从事微环境响应性智能化多功能纳米载药体系的设计与构建及其用于药物靶向输送、分子成像和癌症诊疗一体化的相关研究。

1. Xue Shen; Xiyang Liu; Tingting Li; Yin Chen; Yang Chen; Pan Wang; Lin Zheng; Hong Yang; Chunhui Wu; Shengqi Deng; Yiyao Liu*. Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy, Frontiers in Chemistry, 2021, 9: 746646 (第一作者)
2. Xue Shen, Tingting Li, Xiaoxue Xie, Yi Feng, Zhongyuan Chen, Hong Yang, Chunhui Wu, Shengqi Deng*, Yiyao Liu*. PLGA-based drug delivery systems for remotely triggered cancer therapeutic and diagnostic applications. Frontiers in Bioengineering and Biotechnology, 2020, 8: 381. (第一作者)
3. Yin Chen#, Xue Shen#, Songling Han, Tao Wang, Jianqi Zhao, Yongwu He, Shilei Chen, Shengqi Deng, Cheng Wang*, Junping Wang*. Irradiation pretreatment enhances the therapeutic efficacy of platelet-membrane-camouflaged antitumor nanoparticles. Journal of Nanobiotechnology, 2020, 18:101. (共同第一作者)
4. Xue Shen, Tingting Li, Zhongyuan Chen, Xiaoxue Xie, Hanxi Zhang, Yi Feng, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu*. NIR light-triggered anticancer strategy for dual-modality imaging-guided combination therapy via a bioinspired hybrid PLGA nanoplatform. Molecular Pharmaceutics, 2019, 16: 1367-1384. (第一作者)
5. Xue Shen, Tingting Li, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Shun Li, Hong Yang, Chunhui Wu, Yiyao Liu*. Luminescent/magnetic PLGA-based hybrid nanocomposites: a smart nanocarrier system for targeted codelivery and dual-modality imaging in cancer theranostics. International Journal of Nanomedicine, 2017, 12: 4299-4322. (第一作者)
6. Yong Huang#, Xue Shen#, Haixia Qiao, Hao Yang, Xuejiao Zhang, Yiyao Liu*, Hejie Yang*. Biofunctional Sr- and Si-loaded titania nanotube coating of Ti surfaces by anodization-hydrothermal process. International Journal of Nanomedicine, 2018, 13: 633-640. (共同第一作者)

获得省部级科研平台开放课题立项，并参与过多项国家级及省部级科研项目，发表SCI论文十余篇，指导多名学生参加省级创新创业训练计划项目并获得立项。
1. 国家自然科学基金委员会, 青年科学基金项目, 11802056, 基于光遗传学技术研究细胞骨架网络对肿瘤细胞群体迁移的调控作用与生物力学机制, 2019-01-01 至 2021-12-31；
2. 国家自然科学基金委员会, 面上项目, 31771079, 功能图案化EQCM生物传感器用于乳腺癌微转移能力和标志物检测的研究, 2018-01-01 至 2021-12-31；
3. 国家自然科学基金委员会, 面上项目, 11772088, 三维基质粘弹性影响乳腺癌细胞凋亡和自噬交互作用的力学生物学机制研究, 2018-01-01 至 2021-12-31；
4. 国家自然科学基金委员会, 面上项目, 81671821, 发光/磁性杂合靶向纳米胶束联合阿霉素和miR-34a治疗肿瘤协同增敏和双模态成像研究, 2017-01-01 至 2020-12-31。