中药活性成分物质基础及构效关系研究；基于活性天然产物的先导化合物合成方法学研究及其衍生和结构修饰改造。

1. Leng HaiJun; Li QingZhu; Xiang Peng; Qi Ting; Dai QingSong; Jia ZhiQiang; Gou Chuan; Zhang Xiang; Li JunLong; Diastereoselective [3 + 1] Cyclization Reaction of Oxindolyl Azaoxyallyl Cations with Sulfur Ylides: Assembly of 3,3'-Spiro[β-lactam]-oxindoles., Organic Letters, 2021, 23(4): 1451-1456
2. Leng, Hai-Jun; Wang, Yu-Ting; He, Xiang-Hong; Xia, Hou-Lin; Xu, Peng-Shuai; Xiang, Peng; He, Qing-Qing; Zhan, Gu; Huang, Wei; Design and Efficient Synthesis of RalA Inhibitors Containing the Dihydro-α-carboline Scaffold., ChemMedChem, 2021, 16(5): 851-859
3. Leng Haijun; Zhao Qian; Mao Qing; Liu Shuaijiang; Luo Menglan; Qin Rui; Huang Wei; Zhan Gu; NHC-catalysed retro-aldol/aldol cascade reaction enabling solvent-controlled stereodivergent synthesis of spirooxindoles., Chinese Chemical Letters, 2021, 32(8): 2567-2571
4. Leng, Hai-Jun; Li, Qing-Zhu; Zeng, Rong; Dai, Qing-Song; Zhu, Hong-Ping; Liu, Yue; Huang, Wei; Han, Bo; Li, Jun-Long; Asymmetric Construction of Spiropyrazolone Skeletons via Amine-Catalyzed [3+3] Annulation, Advanced Synthesis & Catalysis, 2018, 360(2): 229-234
5. Leng, Hai-Jun; Peng, Fu; Zingales, Sarah; Huang, Wei; Wang, Biao; Zhao, Qian; Zhou, Rui; He, Gu; Peng, Cheng; Han, Bo; Core-Scaffold-Inspired Asymmetric Synthesis of Polysubstituted Chiral Hexahydropyridazines that Potently Inhibit Breast Cancer Cell Proliferation by Inducing Apoptosis., Chemistry-A European Journal, 2015, 21(50): 18100-18108

1. 参与国家自然科学基金面上项目：杂原子取代醛类化合物在新型有机小分子催化模型中的不对称环化反应研究，21871031，2019-2022，63万元。
2. 参与国家自然科学基金青年项目：基于中药配位化学理论研究中药白芍诱导自噬治疗PD的药效物质基础和分子网络，81603281，2017-2019，18万元
3. 主持成都大学校资助项目：基于靶标网络调控研究螺环氧化吲哚生物碱治疗BC的作用机制，2018XZB02，2018-2019，1.5万元
4. 负责与成都中医药大学签订的横向合同：新型螺环吲哚生物碱衍生物工艺技术服务合同，H1923，2022-2023，15万元